Objective TRIB3 has been confirmed to participate in and regulate biological metabolic activities in head and neck tumors such as nasopharyngeal carcinoma and oropharyngeal carcinoma, so the purpose ...

BV2 cells, once cultured, were grown in 24-well plates for an entire night. Upon achieving a cell density near 60% - 70%, there was an overexpression of SIRT1 (OE-SIRT1) and TRIB3 (OE-SIRT1), as per ...

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Mechanistically, overexpression of SIRT1 inhibits the expression of TRIB3 by inhibiting Smad3 nuclear metastasis, thereby activating autophagy, inhibiting microglial overactivation and alleviating the ...

The second group, constituted by ADM2, TRIB3, CHAC1 and SESN2, is involved in the unfolded protein response (UPR) and finally the third group contains KIF20A, RAD54L and ESPL1, which are involved in ...

In 2009, I joined the University of Sheffield as a Senior Research fellow on a CRUK funded programme grant. Here I set up the lab to study cancer metabolism by Hyperpolarised Magnetic Resonance ...

My overarching research focus is to understand how immune activation is linked to heart disease. Following a severe infection like pneumonia, individuals are at a higher risk of heart attack or stroke ...

The stock market has reacted favourably to The Gym Group’s year-end results which reflect strong growth thanks to multiple ...

Glioblastomas are the most prevalent primary brain tumors and are associated with a dramatically poor prognosis. Despite an intensive treatment approach, including maximal surgical tumor removal ...

The study conducted by Fang et al. offers significant and fundamental insights, notably enhancing our understanding of angiogenesis. While some of the claims are supported by convincing experimental ...

Correspondence to Professor Peter A B Wark, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and School of Medicine and Public Health, The University of Newcastle, ...