Consequently, treatment of hepatocytes with ethanol resulted in TXNIP overexpression, activating NLRP3 inflammasome and caspase-1-mediated pyroptosis. These events were reversed by miR-148a mimic or ...

primarily by inhibiting the activation of the ROS-TXNIP-NLRP3 pathway (Wang et al., 2020). Regarding cardiac fibrosis, FMN improved mitochondrial function by downregulating MOAB mRNA expression and ...

Zhao et al. (2015) reported that both of them could inhibit the production of ROS, the phosphorylation of IRE1α and the subsequent activation of TXNIP/NLRP3, inhibit ROS/ERS/inflammation, and play an ...

BIRMINGHAM, Ala.--(BUSINESS WIRE)--TIXiMED Inc. (www.tiximed.com), a clinical-stage pharmaceutical company based on the breakthrough discovery that TXNIP plays an important role in the development ...

Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, P. R. China Key Laboratory of Advanced Technologies of Materials Ministry of Education, School ...

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China. (Y.E.L., S.L., Litao Wang, Y.D., L. Wu, H.C., T ...

The Western Australian preterm birth prevention initiative: a whole of state singleton pregnancy cohort study showing the need to embrace alternative models of care for Aboriginal women.

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.