In this context, we recently demonstrated that the interaction between the costimulatory protein CD40 and its downstream adaptor protein tumor necrosis factor receptor-associated factor 6 (TRAF6 ...

Herpesvirus-encoded microRNAs (v-miRNAs) play a crucial role in modulating host cellular processes to promote viral persistence, immune evasion, and pathogenesis. These v-miRNAs function by targeting ...

1Department of Experimental Pathology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan. 2Department of Otolaryngology, Head and Neck Surgery, Institute of Medicine, University of Tsukuba, ...

LPS binds to TLR4, activates the MyD88-IRAK-TRAF6 pathway, and induces IKKβ activity within the IKK2 complex. Likewise, by binding IL-1R, IL-1α and IL-1β promote IKKβ activity through the ...

Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Macrophages are important components of the internal immune cells, which profoundly affects the internal ...

Macrophages play a central role in initiating, maintaining, and terminating inflammation. For that, macrophages respond to various external stimuli in changing environments through signaling pathways ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

2 Department of Rheumatology and Clinical Immunology, Semmelweis University, Budapest, Hungary 4 Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary 5 Heart and ...

We are entering an era of medicine where increasingly sophisticated data will be obtained from patients to determine proper diagnosis, predict outcomes and direct therapies. We predict that the most ...

2 Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China Correspondence to Hua Chen, Department of Rheumatology and Clinical Immunology, Peking Union Medical ...