A groundbreaking study led by researchers at Insilico Medicine has revealed the potential of TNIK inhibition as an innovative anti-aging strategy.

In general, chemotherapy medications work by attacking cells or by preventing them from growing and dividing. Cancer cells tend to grow and divide rapidly and uncontrollably, and many chemotherapy ...

1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...

We induced intracranial aneurysms on chimeric mice with partial bone marrow transplantation of TET2-knockout hematopoietic stem cells, widely used to recapitulate human CHIP to test our hypothesis.

Neurons are cells in the body that are responsible for transmitting electrical signals through the nervous system. Different types of neurons affect the ability to move, which begins as an impulse, or ...

The Senescence Accelerated Mouse-Prone 8 (SAMP8) is a naturally occuring mouse line that displays a phenotype of accelerated aging. While maintaining an inbred AKR/J line in the early 1970's, ...

Finally they demonstrate in the cell lines that overexpressing TET2 leads to loss of MOF and increased PTEN and p16, linking TET2 to a regulatory mechanism with these factors that may influence ...