The 'longevity protein' SIRT5 could be a key factor in delaying age-related skeletal muscle decline
A collaborative study led by Prof. Liu Guanghui from the Institute of Zoology of the Chinese Academy of Sciences and Dr. Wang ...
EMBO Press1d
PARP7 as a new target for activating anti-tumor immunity in cancer
PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...
Mirage News4d
SIRT5: Key to Slowing Age-Related Muscle Decline
A collaborative study led by Prof. LIU Guanghui from the Institute of Zoology of the Chinese Academy of Sciences and Dr. WANG Si from Xuanwu Hospital ...
Knowridge Science Report19h
Scientists find the key to slowing down muscle aging
A team of scientists from China has made a breakthrough in understanding how aging affects muscles and found a possible way ...
BioWorld9d
National Institute of Biological Sciences patents new IKBKE1 and TBK1 inhibitors
National Institute of Biological Sciences has disclosed pyrazole urea derivatives acting as inhibitor of nuclear factor κB kinase subunit ε (IKBKE; IKK-i) and/or TANK-binding kinase 1 (TBK1; NAK; T2K) ...
Scientific Research Publishing23d
The Role of Human Herpesvirus-Encoded MicroRNA in Host Virus Interaction ()
Herpesvirus-encoded microRNAs (v-miRNAs) play a crucial role in modulating host cellular processes to promote viral persistence, immune evasion, and pathogenesis. These v-miRNAs function by targeting ...
BMJ22d
Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunction
He died ~16 months after the onset of symptoms. Genetic testing identified a heterozygous two base pair deletion in the TBK1 gene (NM_013254.3:c.2099_2100del; p.(Val700Glyfs*2); online supplementary ...
C&EN23d
Oral Lipid-Based Nanomedicine for the Inhibition of the cGAS-STING Pathway in Inflammatory Bowel Disease Treatment
3.4. LNC(H-151) Reduces TBK1 Expression and the Phosphorylation of TBK1 and STING in J774 Macrophages Macro/microscopic observations revealed that OR LNC(H-151) treatment resulted in comparable ...
Frontiers22d
Mitochondrial control of innate immune responses
Upon RNA virus infection, the protein TBK1 phosphorylates and inactivates the mitochondrial fission protein DRP1, critical for the fusion of mitochondria and the aggregation of MAVS for activation.