The aim is to uncover aberrant metabolic phenotypes applying the ag-TIDEs approach to try to offer a mechanistic explanation to the observed synergies in the combinatorial drug treatments of TAK1, MEK ...

Apoptosis signal-regulating kinase 1 (ASK1) and TGF-β-activated kinase 1 (TAK1) are crucial intracellular signal transduction components that are activated by post-transcriptional modification, and ...

Chronic inflammation refers to a prolonged inflammatory response that involves a progressive change in the type of cells present at the site of inflammation. It is characterized by the ...

Rapid activation of adenosine monophosphate-activated protein kinase (AMPK) induces phosphorylation of mitochondrial-associated proteins, a process by which phosphate groups are added to regulate ...

2 Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China Correspondence to Hua Chen, Department of Rheumatology and Clinical Immunology, Peking Union Medical ...

Molecular cloning, expression and functional characterization of interferon-γ-inducible lysosomal thiol reductase (GILT) gene from mandarin fish (Siniperca chuatsi).

Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany Correspondence to Dr Christoph Becker, 1. Department of Medicine, University of Erlangen-Nuremberg, Hartmannstrasse 14, 91 ...

Medicinal Chemistry Research Group and National Drug Discovery and Development Laboratory, HUN-REN Research Centre for Natural Sciences, 2 Magyar tudósok krt, Budapest 1117, Hungary ...