This dual action—targeting both protein aggregation and mitochondrial dysfunction—positions TFE3 as a promising therapeutic candidate for Parkinson's disease. By bolstering the brain's natural ...

TFE3 overexpression attenuates α-Syn toxicity in a mouse model of Parkinson's disease. TFE3 overexpression rescues autophagy defects of dopaminergic neurons in the AAV-α-Syn model. TFE3 ...

TFE3 overexpression attenuates α-Syn toxicity in a mouse model of Parkinson's disease. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative ...

Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved Insulin ...

However, it is not known whether TFEB plays a role in cholesterol clearance in NPC disease. Here, we show that transgenic overexpression of TFEB, but not TFE3 (another member of MiTF family) ...