Among other functions, the NK cells (natural killers, a type of lymphocyte forming part of the immune system) have the capacity to detect and eliminate cancer cells. But in some cases they cannot ...

A team of researchers from the Hospital del Mar Research Institute, the Universitat Autònoma de Barcelona and the Pompeu Fabra University has developed a new tool that allows modifying these NK cells ...

A team of researchers from the Hospital del Mar Research Institute, the Universitat Autònoma de Barcelona and the Pompeu ...

Despite the high incidence of brain metastasis after resection of non-small cell lung cancer (NSCLC), the National Comprehensive Cancer Network guidelines do not recommend central nervous system (CNS) ...

TX45 Phase 1b trial interim analysis demonstrated meaningful improvements in both left ventricular function and pulmonary hemodynamics in ...

The authors show that knocking out SMAD4, human NK cells resist TGFβ and activin A suppression and demonstrate that SMAD4 knockout enhances the antitumor function of several NK cell products in ...

Some genetic diseases, such as hereditary hemorrhagic telangiectasia or capillary malformation-arteriovenous malformation, happen due to the germline mutation of (ENG, ACVRL1, SMAD4) and (RASA1, EPHB4 ...

Mutations in mothers against decapentaplegic homolog 4 (SMAD4), associated with juvenile polyposis, and in growth differentiation factor 2 (GDF2, also known as BMP-9), are much rarer (3, 4).