Nephron formation in the MM requires reciprocal interaction with the UB tips. The proper elaboration of the UB tree and the secretion of tip-derived signals are essential for adequate nephrogenesis.

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METHODS An isolated vascularly perfused rat colon model was used. Mucus secretion was induced by a variety of luminal factors administered as a bolus of 1 ml for 30 minutes in the colonic loop. Mucin ...

In this valuable contribution, the authors present an approach based on a complex systems theoretical framework to characterize diet-host-microbe interactions and to develop targeted bacteriotherapies ...

Gut microbiota has become a topical issue in unraveling the research mechanisms underlying disease onset and progression. As an important and potential “organ,” gut microbiota plays an important role ...

The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role. C3a/C3aR has dual roles and may exert ...

The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead ...

An Asian woman in her 70s was started on trimethoprim-sulfamethoxazole (TMP-SMX) for treatment of her left fourth toe osteomyelitis. During the course of her therapy, she developed renal tubular ...

S47 There is a large natural variation in nephron numbers between typical two-kidney individuals, and there is an association between nephron number and BP. S51 The hypothesis follows that any ...