Janus kinase (JAK) inhibitors look to be a good treatment option for the newly recognized, rare autoimmune disease known as SOCS1 insufficiency, researchers found. Which was not exactly a surprise.

KSQ-001EX, an engineered tumor-infiltrating lymphocyte (eTIL) therapy in which TIL are edited to inactivate the SOCS1 gene, and KSQ-004EX, an eTIL therapy in which TIL are edited to inactivate the ...

cInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany dInstitute of Genetic ...

The drops they developed contained a SOCS1-KIR mimetic peptide. This is a synthetic molecule that mimics a building block of a protein used in many types of therapies. A SOCS1-KIR peptide is a ...

The primers were used in Table 2. MiR-221-3p target gene prediction was conducted with TargetScan Mouse 7.2. To validate the interaction between miR-221-3p and Socs1, a luciferase reporter assay was ...

IL-27 (IL-27p28, Ebi3) binds to receptor IL-27rα and gp130 and activates downstream signaling including ERK, NF-κB, AP-1, and JAK2, and then regulates activation of cascades STAT1/STAT3 and ...

A petition for rehearing en banc has been filed seeking review of the Fifth Circuit's panel decision in United States v. Peterson, which held that noise suppressors (aka silencers or mufflers) are ...

U.S. inflation data for February will be the highlight among economic data as investors continue to follow the back-and-forth of U.S. President Trump’s announcements on tariffs. A rate decision ...