However, a former president of the Pikes Peak Association of Realtors (PPAR), Gordon Dean, points out that in his experience, sellers in the Colorado Springs market are very savvy. "I've been ...

There was little progress in the treatment of PBC for years until Ipsen's PPAR agonist Iqirvo (elafibranor) was approved in the US, EU, and UK this year for adults with PBC who have an inadequate ...

Until very recently, there were no second-line options for patients with PBC other than Ocaliva in the EU, although, that changed in September when Ipsen's PPAR agonist Iqirvo was approved by the ...

State Key Laboratory of Swine and Poultry Breeding Industry, South China Agricultural University, Guangzhou, Guangdong 510642, China Guangdong Academy of Agricultural Sciences, Guangzhou, Guangdong ...

The PPAR-γ coactivator (PGC)-1 family of proteins plays a central role in these pathways. The mechanisms by which PGC-1 proteins regulate transcriptional networks and are regulated by physiological ...

Objective Previous work has established that the deacetylase sirtuin-1 (SIRT1) is cleaved by cathepsin B in chondrocytes subjected to proinflammatory stress, yielding a stable but inactive N-terminal ...

41 compounds in SQP were identified. Network pharmacology suggested SQP ameliorates CKD and OA by modulating cellular senescence, with SIRT1, RELA, and NFKB1 as key targets. In vivo, SQP improved ...

These include mTOR (mammalian target of rapamycin); sirtuins (SIRT1 [sirtuin 1], SIRT3 [sirtuin 3], and SIRT6 [sirtuin 6]); and AMPK (adenosine monophosphate–activated protein kinase; Figure 3).

Find more information on the Altmetric Attention Score and how the score is calculated. High-throughput screening against the human sirtuin SIRT1 led to the discovery of a series of indoles as potent ...

Department of Pharmacology, Faculty of Pharmacy, King Abdulaziz University, Kingdom of Saudi Arabia Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt Correspondence to: Dr.