Betulinic acid activates the Sirt1/FOXO1 pathway while inhibiting autophagy, thereby ameliorating brain damage subsequent to ischemic stroke (Zhao Y et al., 2021). The natural compound magnoflorine, ...

Department of Rehabilitation Medicine, Qujing No. 1 Hospital, Qujing, China. To sum up, the objective of this research was to thoroughly explore SIRT1’s role and interplay in controlling microglial ...

the authors show how STAMBPL1 promotes TNBC angiogenesis via a feed-forward GRHL3/HIF1a/VEGFA axis. They demonstrate that STAMBPL1 interacts with FOXO1, define the required domains in each protein, ...

In cultured hepatocytes and mouse livers, alcohol exposure inhibited forkhead box protein O1 (FoxO1) expression, which correlated with miR-148a levels and significantly decreased in human AH specimens ...

The study presents valuable findings regarding the incidence and clinical impact of a mutation in a cardiac muscle protein and its association with the development of atrial fibrillation. The authors ...

The regulation of ferroptosis is extremely complex and is closely associated with a spectrum of diseases. Sirtuin 1 (SIRT1), a NAD + -dependent histone deacetylase, has emerged as a pivotal epigenetic ...

Mission Statement: Evidence-based Complementary and Alternative Medicine (eCAM) is an international, peer-reviewed journal that seeks to understand the sources and to encourage rigorous research ...

The Buddhasothorn Asthma Severity Score (BASS): A practical screening tool for predicting severe asthma exacerbations for pediatric patients.

FoxO3-AS knockdown reduced FoxO3 levels by 78% and also reduced Pten and Sirt1 levels; Pten-AS knockdown reduced Pten by 37% while reducing FoxO3 levels by 60%, a larger reduction than that of Pten; ...