For example, significant hepatic lipid accumulation is observed in a mouse model in which the hepatocyte histone methyltransferase Setdb1 is knocked out. In this process, upregulated miR-216b-5p binds ...

SUMOylation of SET structural domain bifurcation 1 (Setdb1) promotes Setdb1 to occupy the promoter site of the Pparg and Cebpa genes. Setdb1 functions as a histone methyltransferase responsible for ...

The basic pattern of genomic DNA methylation is established at the time of embryo implantation through a wave of de novo methylation, but CpG islands are protected through a mechanism that ...