eLife28d
Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis
This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...
SciELO6d
circLOC375190 promotes autophagy through modulation of the mTORC1/TFEB axis in acute ischemic stroke-induced neurological injury
circLOC375190 affects AIS autophagy by regulating the mTORC1/TFEB axis. Therefore, to provide a theoretical foundation for the treatment of AIS, the authors explored the specific mechanism of ...
Frontiers23d
Increased PRR14 and VCAM-1 level in serum of patients with Parkinson's disease
Background: Regarding the complexity of Parkinson's disease (PD), the identification of reliable biomarkers is of great significance for improving the accuracy of diagnosis and monitoring disease ...
Frontiers16d
Application status and research progress of targeted therapy drugs for hormone receptor-positive breast cancer
1 Department of Breast Surgery, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China 2 Department of Breast Surgery, The First Affiliated Hospital of Hainan ...
gut.bmj22d
Targeting mTOR dependency in pancreatic cancer
7 The Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK 8 Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University ...
BMJ22d
Autophagy activation by rapamycin reduces severity of experimental osteoarthritis
Both ROS accumulation and mTORC1 activation are associated with accelerated ageing and the development of ageing-associated pathologies.41 42 Conversely, a reduction of ROS levels by antioxidants or ...