By interacting with RUNX1, a critical transcription factor, JMJD1C drives leukemia cell survival, making it a compelling therapeutic target. This discovery sheds light on how molecular mechanisms ...

Emeritus Professor of Experimental Haematology, Constanze Bonifer, wins prestigious award for advancing her field of research.

Favorable mutations include PML::RARA and RUNX1::RUNX1T1, while adverse mutations involve TP53, FLT3, and KMT2A rearrangements. The use of cytogenetics, FISH, and NGS panels aids in classification ...

Laboratory analyses showed that the patient who developed AML had significant chromosomal abnormalities and mutations in the RUNX1 and PTPN11 genes typically associated with the development of the ...

Researchers have discovered that the protein JMJD1C plays a pivotal role in leukemia cell survival. Specifically, JMJD1C is recruited by RUNX1 to genomic loci, where it forms liquid-like condensates.

Introduction: Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies that target the neuromuscular junction, leading to muscle weakness and fatigability. Diagnosis is based on ...

Transgenic animals continue to play an essential role in many aspects of zebrafish research, including the development of disease models. The most widely used system for zebrafish transgenesis is the ...

Although there is no cure, diabetic retinal disease treatment has improved over the past two decades. Diabetes affects more than 1 in 10 adults worldwide and has been accompanied by an increase in ...

Treatment stratification in ALL includes diverse (cyto)genetic aberrations, requiring diverse tests to yield conclusive data. We optimized the diagnostic workflow to detect all relevant aberrations ...

Single-cell multiomic analyses reveal known and new genes and pathways involved in the development of germ cells and provide a discovery platform for the scientific community.