Kinases are enzymes that catalyze the addition of a phosphate group (PO43−) to substrates, usually proteins ... but the design of highly selective kinase inhibitors remains challenging.

E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...

BYU Professor David Thomson is working to understand a chemical pathway in human muscles that may explain the effects of exercise.

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

Pharmaceutical ads are difficult to avoid in American television programming and a growing number of them promote a class of medications called JAK inhibitors, using an acronym that assumes the ...

The biochemical profile and milk fats/proteins in Saanen and Nubian goats from Los Asmoles, Colima was carried out. Milk fat, milk protein, fat/protein ratio, glucose (GLU), cholesterol (COL), ...

The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates ...

Molecular Cancer Therapeutics publishes articles on the discovery and preclinical development of novel therapeutic agents for oncology, preclinical studies of approved therapeutics, mechanisms of drug ...

“I have a subscription for this product. I started taking this because of its high protein content in comparison to the original white powder formula. It has an extra 10 g of protein, with every ...

Melanoma brain metastasis is linked to dismal prognosis and low overall survival and is detected in up to 80% of patients at autopsy. Circulating tumor cells (CTC) are the smallest functional units of ...

Misregulation of protein–protein interactions (PPIs) underlies many diseases; hence, molecules that stabilize PPIs, known as molecular glues, are promising drug candidates. Identification of novel ...