uhnresearch.ca Objectives We have previously shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor ... It has been shown that agonists of PPARγ exhibit ...

Get Instant Summarized Text (Gist) A new technology using a light-activated compound has been developed to target drug-resistant cancer cells by suppressing autophagy, a key resistance mechanism ...

The NHS had been facing supply issues with glucagon-like peptide receptor agonists (GLP-1 RAs, or GLP-1 analogues), a range of drugs used for managing blood glucose levels in people with type 2 ...

Depending on the severity, there are different therapeutic options (topical medications, phototherapy, systemic drugs, etc ... of the other adenosine receptors. "This activation has an anti ...

Objective To determine the expression of PPARs in human fibrotic skin and investigate the effects of IVA337, a pan PPAR agonist, in in vitro and in vivo models of fibrosis. Methods The antifibrotic ...

inserm.fr; Professor Patrice D Cani, Louvain Drug Research Institute ... and the presence of mu-opioid receptors (MOR) on enteric neurons. Using pharmacological approaches, we demonstrated the key ...

dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...

And guess what’s also found in joint tissues? GLP-1 receptors. So it turns out that GLP-1 drugs may be able to target and ease the low-grade local inflammation of the synovium that causes such ...

GLP-1 receptor agonist drugs are not just shaking up the world of obesity and diabetes medicine: a growing body of research suggests these drugs could help prevent and possibly treat Alzheimer’s ...