Yahoo Finance23d
Hoth Therapeutics Announces Positive Findings on GDNF's Potential as a Game-Changer in Obesity Treatment and Reduced Fatty Liver Disease
Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved Insulin ...
BioSpace23d
Hoth Therapeutics Announces Positive Findings on GDNF’s Potential as a Game-Changer in Obesity Treatment and Reduced Fatty Liver Disease
Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved Insulin ...
Frontiers28d
Research progress on ferroptosis in Myelodysplastic syndromes
A set of six feature genes (SREBF1, PTPN6, PARP9, MAP3K11, MDM4, EZH2) demonstrated high accuracy in MDS diagnosis. These findings underscore the complex relationship between FRGs and MDS (Zhu et al., ...
Frontiers11d
Role of genetic variants and DNA methylation of lipid metabolism-related genes in metabolic dysfunction-associated steatotic liver disease
PPAR, peroxisome proliferator-activated receptor; SREBP, sterol regulatory element-binding protein; NEFA, non-esterified fatty acids; FFAs, free fatty acids. Apart from the regulation of DNL, ...
gut.bmj15d
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
PPARα is less expressed in the liver of patients with non-alcoholic fatty liver diseases (NAFLD). Several PPAR-targeting molecules, including dual agonists, are currently under investigation for NAFLD ...