Functional analyses revealed that this change attenuates the ability of Nef to stimulate PI3K/Akt/mTORC2 signalling. The authors propose that this improved induction of SIVmac239 nAb is reciprocal to ...

Functional analyses support that this mutation specifically impairs Nef`s ability to stimulate PI3K/Akt/mTORC2 signalling. This important study suggests that the accessory viral protein Nef impairs B ...

early glycolysis is NOS2 independent and mediated by TBK1-IKKε-AKT pathway and long-term glycolysis is raised by PI3K-AKT-mTOR signal (98). mTOR forms two complexes, the mTORC1 and mammalian target of ...

I joined the University of Sheffield in 1988 as a postdoctoral researcher and was working on the development and implementation of a novel genetic screening approach. This is based on detecting the ...

For One University Strategy enquiries in the Faculty of Health, please contact Isabel Andrews. I joined the University of Sheffield in 1990 after a BBSRC CASE PhD studentship at the University of ...

Knock-down of TRIB3 expression suppresses the growth, invasion and migration of LSCCs via PI3K / AKT / mTOR. TIME analysis, surface checkpoint analysis, and prediction model indicated that TRIB3 ...

Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles ...

Hepatocellular carcinoma (HCC) poses a serious threat to human health. Identifying diagnostic and therapeutic targets from plasma proteins is essential for early HCC detection and treatment.

7 The Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK 8 Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University ...

6 NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Sandwell and West Birmingham NHS Foundation Trust & Institute of ...