Functional analyses revealed that this change attenuates the ability of Nef to stimulate PI3K/Akt/mTORC2 signalling. The authors propose that this improved induction of SIVmac239 nAb is reciprocal to ...

Diacylglycerol kinases (DGKs) are a family of enzymes that regulate the relative levels of diacylglycerol (DAG) and phosphatidic acid (PA) in cells by phosphorylating DAG to produce PA. Both DAG and ...

The strong shear stress altered the membrane lipid microdomain structure of endocardial cells, which activated mTORC2 and PKC and promoted Notch1 cleavage even in the absence of strong ligand ...

Akt, protein kinase B; AS160, Akt substrate of 160 kDa; GLUT4, glucose transporter 4; GSK3, glycogen synthase kinase 3; IRS-1/2, insulin receptor substrates 1 and 2; mTORC1/2, mechanistic target of ...

7 The Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK 8 Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University ...

Certain nutrients have been shown to support healthy blood sugar metabolism. For example, cinnamon has been found to reduce fasting blood sugar levels by enhancing insulin sensitivity (5).