S-2-hydroxyglutarate produced by CD8+ T cells under hypoxic conditions affects locus-specific histone and DNA methylation patterns, which enhances T-cell proliferation, survival and recall responses.

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The most malignant neuroblastomas harbor amplification of the MYCN oncogene, found in approximately 20 to 30% of patients (7, 8). MYCN amplification is associated with aggressive disease and poor ...