[19] Potentially important platelet mediators include platelet-derived growth factor (PDGF), TGF-beta 1, and epidermal growth factor (EGF). Fibrogenesis. Increased matrix production is the most ...

Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways. Over 10,000 patients have ...

Additionally, her research identified emerging biomarkers, such as the PDGF pathway, which governs the recruitment of pericytes essential for maintaining BBB integrity. By leveraging human tissue ...

Objective Systemic sclerosis-associated pulmonary arterial hypertension differs from idiopathic pulmonary arterial hypertension with respect to histopathology, treatment responses and survival.