Frontiers6d
Beyond protein degradation and lysine modification: novel insights into non-canonical ubiquitination
Furthermore, a number of ubiquitin-like (UBL) modifiers (NEDD8, SUMO, ISG15, UFM1, FAT10, URM1) have also been identified. The study of canonical Ub and UBL proteins has led to a greater understanding ...
pharmaphorum3d
FDA knocks back Takeda's blockbuster hope TAK-721
In September it claimed approval for first-in-class lung cancer therapy Exkivity (mobocertinib), but that followed disappointments with NEDD8-activating enzyme inhibitor pevonedistat – which ...
scienceopen.com27d
Coumarin derivatives as inhibitors against monoamine oxidase: structure-activity relationships and inhibitory mechanisms
After combining all the results, the structure-MAO inhibition relationship of the coumarins is summarized in Figure 2C. Notably, phenyl substitution had a unique effect on MAO inhibitory activity and ...
C&EN27d
Phase Separation Clustering of Poly Ubiquitin Cargos on Ternary Mixture Lipid Membranes by Synthetically Cross-Linked Ubiquitin Binder Peptides
Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Ubiquitylation is involved in various physiological processes, such as signaling and ...
C&EN26d
Unveiling Molecular Fingerprints of Bacteria on Nanoplasmonic Sensors
UNAM─National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey ...