Osteolytic bone disease is a frequent complication of multiple myeloma ... development of novel drugs for the management of lytic disease in myeloma. Currently, bisphosphonates are the mainstay ...

Computed tomography (CT) is a sensitive tool for detection of the bone-destructive effects in MM as it can detect small osteolytic lesions ... is a hallmark of multiple myeloma (MM), associated ...

25, 2025 — A bone marrow ... Disease in Multiple Myeloma Jan. 14, 2025 — A team of researchers has developed a new biomaterial with high potential in in the treatment of bone lesions or ...

Pim-2 kinase is overexpressed in multiple myeloma (MM) cells to enhance their ... in MM by multiple factors overproduced in MM bone lesions, and because Pim-2 acts as a negative regulator of ...

Multiple myeloma, an incurable type of bone marrow cancer, often develops unnoticed in the bone marrow over decades. In advanced stages, lesions form that can destroy the bone and spread to other ...

Purpose: Current treatment guidelines strongly support the use of antiresorptive therapy in patients with newly diagnosed multiple myeloma ... patients with existing lytic lesions, osteoporosis or ...

Multiple myeloma is a type ... that grow and multiply uncontrollably in bone marrow. While genetic changes to the DNA are what may cause multiple myeloma, abnormal chromosomes may contribute ...

It develops when a normal plasma cell changes into a myeloma cell, which can multiply uncontrollably. Multiple myeloma symptoms include bone pain or fractures, backache, frequent infections, weight ...

Whilst the ultimate outcome of the lytic cycle is production of new phage progeny and death of the host bacterial cell, this is a multistep process involving precise coordination of gene transcription ...