Under cellular stress, mTOR reduces its inhibition on the ULK1-FIP200-ATG13 complex, whereas AMPK reduces mTORC activity and directs ULK-1 to the site of autophagy. The ULK-1 complex regulates the ...
In this manuscript, Sur and colleagues present insights into the potential pathways and mechanisms underlying the pathogenesis of cystinosis - a prototypical lysosomal storage disorder caused by the ...
Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Cerebral dysfunctions give rise to a wide range of neurological diseases due to the ...
1 The First Clinical Medical School, Guangdong Medical University, Zhanjiang, Guangdong, China 2 The First People’s Hospital of Zhaoqing, Guangdong Medical University, Zhaoqing, Guangdong, China As a ...
Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...
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