Original paper11d
Assessment of the status of DNA mismatch repair proteins by immunohistochemistry. Proposal for evaluation with two antibodies
Patients with adenocarcinoma and MMR determination were reclassified using only the evaluation of PMS2 and MSH6. The diagnostic performance of the 2-antibody test (proposed panel) and 4-antibody ...
Frontiers22d
Computational Tools for Splicing Defect Prediction in Breast/Ovarian Cancer Genes: How Efficient Are They at Predicting RNA Alterations?
A discovery dataset of 99 variants with unequivocal results of RNA in vitro studies, located in the 10 exonic and 20 intronic nucleotides adjacent to exon–intron boundaries of BRCA1, BRCA2, MLH1, MSH2 ...
Frontiers23d
SMARCA4-deficient undifferentiated carcinoma co-existing with primary endometrial gastric (or gastrointestinal) -type carcinoma: a case report
Immunohistochemical analysis revealed positivity for CDX2, SATB2, CK7, CK20, PMS2, MLH1, MSH2, MSH6, and wild-type p53, while showing negativity for p16, Pax-8, ER, PR, Muc-6, Muc-5AC and claudin 18.2 ...
ascopubs.org19d
Real-World Utilization and Performance of Circulating Tumor DNA Monitoring to Predict Recurrence in Solid Tumors
Impact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma This retrospective analysis included patients with cancer who had commercial ctDNA tests (K-Track, Gene ...
ascopubs.org26d
Expanding Germline Hereditary Cancer Gene Panel Testing by Nongenetics Providers: 3-Year Experience in Large Integrated Health Care Delivery System
Assessing Clinical Value of New Treatment Strategies: ESMO-MCBS and ASCO-VF Evaluation in Phase III Trials at ASCO Annual Meeting 2022 Demand for germline hereditary cancer genetic testing has ...
Nature19d
How nucleotide excision repair protects against cancer
Living cells respond to DNA damage by a variety of mechanisms, including a series of biochemical pathways called DNA repair. These include three discrete pathways for the excision of damaged bases ...
BMJ20d
Advances in the management of endometrial cancer
1 Division of Gynecologic Oncology, University of Colorado Hospital, Aurora, CO, USA 2 Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MO, USA 3 Division of Gynecologic ...
casereports.bmj6d
Unusual extra-axial high-grade glioma in a young child with Lynch syndrome
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
The Lancet23d
ICGC-ARGO precision medicine: an update on familial matters in pancreatic cancer
aDepartment of Medicine, University of Verona, School of Medicine and University Hospital Trust of Verona (AOUI Verona), Verona 37134, Italy bDepartment of Diagnostics and Public Health, and ARC-Net ...
Cancer Research6d
Prevalence of Mismatch Repair Deficiency in Primary Prostate Cancer in a Large Prospective Cohort
1Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland. 2Department of Medical Oncology, St. James’s Hospital, Dublin, ...