The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death.

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is ...

Ferroptosis, a form of programmed cell death mediated by iron, has been a focus for its potential in cancer therapies. Now, ...

New research has found that lipid peroxidation of lysosomes plays a critical role in the execution of ferroptosis.

A new study shows that dysfunction of lysosomes can cause leakage of toxic substances within brain cells, contributing to ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

Previous research has identified that mutations in the GBA1 gene result in decreased lysosomal glucocerebrosidase (GCase) activity – a key enzyme for lysosome function – and are linked to increased PD ...

Lysosome impairment contributes to many diseases, including Alzheimer's, Parkinson's, and Huntington's disease. A better understanding of lysosomal function may lead to new therapeutic strategies for ...

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Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.