The research team discovered that activation of this stress pathway, known as the integrated stress response (ISR), prompts microglia to produce and release toxic lipids. These lipids damage ...

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...

The body's stress response is a powerful and wonderfully integrated series of responses that under normal conditions functions to facilitate fight/flight responses, restore homeostasis, and promote ...

The Lloyd Lab main research focus is the enterovirus infection triggers of integrated stress responses and Type 1 Diabetes. Enteroviruses such as poliovirus and coxsackievirus shut off cap-dependent ...