Patients with loss-of-function mutations in IL10 or IL10 receptor (IL10R) genes develop severe, medical-refractory, infantile-onset inflammatory bowel disease (IBD). We have previously reported ...

and astrocytes by expressing immune checkpoint molecules or by secreting immune-suppressive cytokines (e.g., IL10, TGFβ or IL6). Moreover, astrocytes with high STAT3 expression were shown to activate ...

BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...

Over the past few decades, the prevalence of chronic inflammatory and metabolic diseases has risen sharply, coinciding with significant environmental and lifestyle changes. While genetics play a role, ...

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