Seismic Therapeutic, Inc., the machine learning immunology company, today announced the presentation of preclinical data for its immunoglobulin E (IgE) protease, S?8484, demonstrating rapid and ...

Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...

The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...

When my co-founder and I started Invoice Home, we wanted to build a business that could grow over time. We noted many inefficiencies while discussing our past experiences working within ...

Conclusions In this cohort of patients with histology-confirmed IgG4-RD, multiparametric CMR revealed no changes in gross cardiac structure and function, but frequent myocardial tissue abnormalities.

Objective IgG4-related disease (IgG4-RD) is a heterogeneous, multiorgan condition of unclear aetiology that can cause organ failure. Difficulty recognising IgG4-RD contributes to diagnostic delays. We ...

Objectives Hypocomplementaemia is common in patients with IgG4-related disease (IgG4-RD). We aimed to determine the IgG4-RD features associated with hypocomplementaemia and investigate mechanisms of ...

(3)Aβ clearance closer to the N-terminus is associated with a higher risk of ARIA-H.(4)mAb with an IgG4 structure are more likely to cause ARIA-H than those with an IgG1 structure.(5)Faster ...

Owing to its small, monomeric structure and high diffusibility, IgG is the most abundant type of immunoglobulin in the extracellular fluid. Its ability to bind Fc receptors on phagocytic or other ...

We found that reporters for Basigin, a cell surface molecule of the immunoglobulin (Ig ... neurons with simpler branching patterns were unaffected by loss of Basigin. Structure-function analyses ...