Some immunoglobulin heavy-chain V genes were associated with viral infections or autoimmune status, aligning with existing immunological knowledge. SARS-CoV-2-specific BCR sequences from external ...

This finding initiated decades of extensive immunochemical studies of immunoglobulin structure ... class switching in the heavy-chain constant region, and increased affinity for antigen in the ...

The properties of the different IgG isotypes should be considered ... evolved the ability to exchange combinations of heavy and light chains. van der Neut Kolfschoten et al. found that IgG4 ...