PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as ...

A conserved molecular pathway controlled by the proteins cGAS, STING and IRF3 can detect DNA outside of these compartments, and report it to the neighbouring and immune cells by secondary ...

A research led by Sergio P. Acebrón, Researcher Ikerbasque at the UPV/EHU, develops a key tool to visualize the immune response to abnormal DNA, opening new avenues for the treatment of diseases.

Cells contain a DNA sensor called cGAS, which alerts the immune system to viral and bacterial infections, cell death, and cancer-related transformations. A research team led by Ikerbasque Research ...

Herpesvirus-encoded microRNAs (v-miRNAs) play a crucial role in modulating host cellular processes to promote viral persistence, immune evasion, and pathogenesis. These v-miRNAs function by targeting ...

Activated STING translocates to the Golgi apparatus, where it activates TBK1, leading to the phosphorylation of both STING and IRF3. Phosphorylated IRF3 dimerizes and induces the transcription of ...

Subsequently, cGAMP-bound STING migrates from the endoplasmic reticulum to the golgi apparatus where it recruits and activates protein kinases TBK1 and IKK, the upstream initiators of the IRF3 and ...

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