University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin ...

One protein mitigates Huntington’s disease while another one exacerbates it by regulating the huntingtin protein’s movement in neurons.

Researchers found that inhibiting GSK-3 led to less defects in the axonal transport process and less neuronal cell death, while inhibiting ERK1 led to more transport problems and more cell death.

The phase 2 PIVOT-HD trial of Novartis-partnered PTC518 (votoplam) showed that the oral mRNA splicing modifier was able to ...

Walks to bring awareness to a rare degenerative disease were held in five Iowa cities over the weekend. Huntington’s disease ...

PTC Therapeutics, Inc. (NASDAQ:PTCT) on Monday announced results from the Phase 2 PIVOT-HD study of PTC518 (votoplam) in ...

Many Fargoans took advantage of the lovely weather this weekend to get their steps in for a good cause. Rheault Farms saw the ...

University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington's disease?

When the HTT gene mutates it repeats the genetic sequences cytosine ... The kinases GSK3ß and ERK1 caught the team’s eye because they were upregulated in neurons with Huntington’s disease when ...

University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated ...