A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and ...

Less is known about the molecular expression of bile transport mechanism in cholestatic liver diseases in humans. However, with a few exceptions, studies of steady-state mRNA and protein tend to ...

Look closely at this image, stripped of its caption, and join the moderated conversation about what you and other students see. By The Learning Network Look closely at this image, stripped of ...

Here, we show that SZN-043 induced hepatocyte proliferation in all models tested, including humanized mouse livers, a chronic-binge alcohol-induced liver injury, and a CCl 4-induced fibrosis mouse ...

Primary mouse hepatocytes were harvested by liver perfusion, as previously reported [31]. Medium containing 100 μM dinitrophenyl S-glutathione (DNP-SG) was used to culture cells for half an hour.

Hypothyroidism disrupted the circadian oscillation of core clock components and the circadian oscillation of L-FABP, CD36, PEPT1, and GLUT2 protein contents in the small intestine of female mice, ...

The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external ...

However, little is known about the role of hepatocyte senescence in AIH pathogenesis. A novel murine AIH model was established by inhibiting hepatocyte cytokinesis. Cellular senescence was assessed ...