Aims To describe and compare clinical features, complications and outcomes in patients with granulomatosis with polyangiitis (GPA)-associated scleritis with those seen in idiopathic and other ...

In this report, we present a typical case of granulomatosis with polyangiitis (GPA) complicated by spontaneous renal hemorrhage (SRH), a rare but potentially severe condition. The patient developed ...

Others, such as eosinophilic granulomatosis with polyangiitis, tend to develop in adults. Symptoms of autoimmune vasculitis can vary depending on the type of condition and which parts of your body ...

Iptacopan hydrochloride (Fabhalta) is a factor B inhibitor of the alternative complement pathway15-17 ... cytoplasmic antibody-associated vasculitis (ANCA Vasculitis), granulomatosis with polyangiitis ...

The complement system is an important part of the humoral immune defence in mammals that is formed by about 35 soluble and cell-surface proteins. Together these proteins enable the host to ...

Mepolizumab has shown promising results in relapsed and refractory eosinophilic granulomatosis with polyangiitis. Other biological agents targeting cytokines, complement, and other pathways have also ...