Background: Non-medical use (NMU) of prescription GABA analogs (pregabalin and gabapentin) has been reported especially in opiate dependent persons. However, by now the prevalence of NMU of ...

Pregabalin is a recently introduced α 2-δ subunit ligand at the voltage- sensitive calcium channel that has shown good efficacy with a tolerable side-effect profile in the treatment of PDN.

Compared with gabapentin, pregabalin was more efficacious and safer for the treatment of neuropathic pain, with significant reductions in pain intensity and duration, opioid use, and adverse events.

Do not start sodium valproate for the first time in people (male or female) younger than 55 years, unless 2 specialists independently agree and document that there is no other effective and tolerated ...

Initially developed to generate new treatments for epilepsy, gabapentin, and pregabalin (“gabapentinoids”) were engineered to mimic the action of GABA and to modulate GABA metabolism. Rather than ...