Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as Colony Stimulating Factor 2 (granulocyte-macrophage), is a cytokine originally identified for its role in promoting the ...

NEW YORK, March 03, 2025 (GLOBE NEWSWIRE) -- Y-mAbs Therapeutics, Inc. (the “Company” or “Y-mAbs”) (Nasdaq: YMAB), a commercial-stage biopharmaceutical company focused on the development ...

The article, titled “The anti-GD2 monoclonal antibody naxitamab plus GM-CSF for relapsed or refractory high-risk neuroblastoma: a phase 2 clinical trial,” details the results of a single-arm, global ...

The FLAMINGO-01 DSMB met twice in 2024, most recently in December 2024, and recommended to continue the study as is without modification. No serious adverse events related to GLSI-100 have been ...

Greenwich LifeSciences (GLSI) announced the following update on FLAMINGO-01 open label safety data. The FLAMINGO-01 DSMB met twice in 2024, ...

The asset licensed from AstraZeneca, GM-CSF antagonist mavrilimumab, was already on the back-burner, but the termination of the midphase autoimmune program comes as more of a shock. Six weeks ago ...

BAD is a pro-apoptotic member of the Bcl-2 family that is tightly regulated by survival factors. Several major signalling pathways influence cell death through their direct effects on the ...

In current clinical practice G-CSF is more commonly used to shorten the period to recovery from chemotherapy induced neutropenia. However, recent interest has focused on the potential clinical benefit ...

and GM-CSF were measured using a Human Magnetic Luminex Assay kit (R&D Systems, USA) on the Bio-Rad Luminex platform (Luminex, USA), according to the manufacturer's instructions. Central tendency was ...

Intracellular staining was then performed with antibodies specific for human IL-17 (eBioscience), IFN-γ, tumour necrosis factor (TNF)-α, IL-22, IL-21, IL-8 (all from BD Biosciences) or ...

Many promising new approaches to mitigate CRS have recently been reviewed, including GM-CSF depletion, JAK/STAT inhibition and transient suppression of CAR-T cell activation with dasatinib amongst ...