eLife24d
STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer
the authors show how STAMBPL1 promotes TNBC angiogenesis via a feed-forward GRHL3/HIF1a/VEGFA axis. They demonstrate that STAMBPL1 interacts with FOXO1, define the required domains in each protein, ...
eLife24d
STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer
In this study, we discovered that STAMBPL1 facilitates the transcriptional regulation of GRHL3 by interacting with FOXO1, consequently enhancing HIF1A transcription through GRHL3 to activate the HIF1α ...
gut.bmj10d
Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression
In cultured hepatocytes and mouse livers, alcohol exposure inhibited forkhead box protein O1 (FoxO1) expression, which correlated with miR-148a levels and significantly decreased in human AH specimens ...
Frontiers23d
An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases
The activated pathways interact with SOCS1 and SOCS3 to regulate the transcription of T-bet, GATA-3, RORγt, Foxp3, Blimp-1, and Foxo1. Blimp-1, B lymphocyte-induced maturation protein-1; Foxo1, ...
Frontiers17d
Roles of extracellular vesicles from different origins in metabolic-associated fatty liver disease: progress and perspectives
1 School of Public Health, Gansu University of Chinese Medicine, Lanzhou, China 2 College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China ...
Fathom20d
The Science Of Blood Sugar Balance Can A Type One Diabetes Live Without Insulin
When cortisol binds to glucocorticoid receptors in fat cells, it activates an enzyme called phosphoenolpyruvate carboxykinase (PEPCK), which promotes gluconeogenesis – the process of generating new ...