The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high ...

The non-stop and no-go decay pathways target mRNAs on which ribosomes are stalled because ... proteins in an organelle called the endoplasmic reticulum), activation of the p38 and JNK pathways ...

A new technique reveals ribosome cooperativity, providing new insights into protein production. Researchers from Marvin Tanenbaum’s group at the Hubrecht Institute (Utrecht, Netherlands) have ...

Additionally, Phosphorylated eIF2α (p-eIF2α) prevents ribosome assembly, which results in a translational ... provides neuroprotection in ischemic stroke. The Role of Endoplasmic Reticulum Stress in ...

"Ribosomes are very large macromolecular machines that very rapidly and precisely decode mRNA into protein. For a long time, they've been viewed as kind of 'dumb code-reading machines' that don't ...

Notably, the ribosome, a ribonucleoprotein complex that is essential for translation on the endoplasmic reticulum (ER) and in the cytoplasm, is recognized as the central organelle during this process.

The endoplasmic reticulum (ER) is the site at which secreted proteins (such as the hormone insulin) and membrane-bound proteins are folded. ATP-dependent chaperones within the ER help proteins fold.

This month's cover highlights the article DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging by Sara Sepe, Francesca Rossiello, Fabrizio d’Adda di ...