The transcription factor E2F1 was predicted as the main effector responsible for the transcriptomic changes in sensitive cells. Western blot and qRT-PCR confirmed upregulation of E2F1 in co-cultured ...
The overexpression of miRNA-16-5p is linked to cell proliferation suppression and modulates the Cyclin D1/E1-pRb-E2F1 pathway, inducing G0/G1 phase arrest after irradiation, which consequently ...
["MYH9..ENSG0004627", "LMNA..ENSG0004000", "HSPG2..ENSG0003339", "EPHB4..ENSG0002050", "CSMD3..ENSG000114788", "FRMPD2..ENSG000143162", "FNDC3B..ENSG00064778 ...
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Background and aims Alcohol-associated hepatitis (AH) is an acute form of alcohol-related liver disease (ALD) with high mortality rate. AH is histologically characterised by cellular processes, ...
Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...
Objective Dysregulated cellular metabolism is a distinct hallmark of human colorectal cancer (CRC). However, metabolic programme rewiring during tumour progression has yet to be fully understood.
1Department of Urology, Stanford University School of Medicine, Stanford, California.