This poster introduces the background of Ubiquitins, applications of Ubiquitins in research, and featured active Ubiquitins ...

CRL4 (Cullin-RING ubiquitin ligase) is an E3 ubiquitin ligase, composed of three subunits DDB1, cullin 4 (CUL4), and regulator of cullins 1 (RBX1/ROC1). This enzyme has great importance in ...

Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Falmer BN1 9QJ, U.K. Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Biomolecular interactions are essential in many biological processes, including ...

This study provides important computational insights into the dynamics of PROTAC-induced degradation complexes, offering a convincing demonstration that differences in degradation efficacy can be ...

Acute myeloid leukemia (AML) is one of the most common hematologic malignancies that is characterized by clonal expansion of abnormally differentiated myeloid blasts (1, 2). High treatment failure ...

At least 250 million people worldwide are chronically infected with HBV, a small hepatotropic DNA virus that replicates through reverse transcription. Chronic infection greatly increases the risk for ...