A recent study published in eLife offers a new perspective on the development of Alzheimer’s disease, suggesting that the ...

A leading hypothesis is that these events are mediated by neurotoxicity of amyloid ... protein precursor (APP) that is the main constituent of senile plaques. Figure 1: APP interaction with and ...

Upon proteolytic cleavage of APP (see insert), Aβ ... Aβ: Amyloid-β; AICD: Amyloid-β precursor protein intracellular domain; APP: Amyloid-β precursor protein; Fpn: Ferroportin; IDE: Insulin ...

γ-Secretase is a presenilin-containing intramembrane aspartyl protease complex that cleaves within the transmembrane domain (TMD) of nearly 150 substrates, with the amyloid precursor protein (APP) ...

Specific cleavage sites are shown by dotted lines ... The former includes EphB receptor tyrosine kinases, integrin, and amyloid precursor protein (APP), while the latter includes ephrin-B and ...

Furin is identified as the key enzyme responsible for cleaving the apelin precursor. Inhibiting this cleavage could serve as ...

Viral infections, for example, might “contribute in some way” to the cascade of pathology that amyloid proteins cause. Nonetheless, his role in strong-arming the field to favor a focus on ...

During her talk, Rice had described how a peptide called amyloid precursor protein (APP) gets broken down in the brain into smaller pieces such as amyloid-β, the peptide that notoriously goes on to ...

Here we demonstrate that a modest increase in astroglial TGF-β1 production in aged transgenic mice expressing the human β-amyloid precursor protein (hAPP) results in a three-fold reduction in ...

Two main protein structures are associated with Alzheimer’s disease: amyloid-beta plaques and neurofibrillary tangles (NFTs). Amyloid-beta: As Alzheimer’s disease develops, amyloid precursor ...