In a related domain, Hernández-Echeagaray et al. explored the role of cyclin-dependent kinase 5 (Cdk5) in modulating synaptic plasticity during the early stages of Huntington's disease (HD). Cdk5 is a ...

Different genetic mutations that can occur include: Continued investigations into the causes of lissencephaly have identified 31 genes that may be involved, including TUBA1A, NDE1, KATNB1, and CDK5.

N1, N2, N-terminal inserts 1 and 2; R1-R4,MT binding repeats 1–4; GSK-3β, Glycogen synthase kinase 3β; Cdk5, Cyclin-dependent kinase 5; CK, casein kinase; MARK, microtubule affinity-regulating kinase; ...

The parts of cells that produce energy, called mitochondria, in the skeletal muscles involved in voluntary movements don’t work properly in spinal muscular atrophy (SMA) and may contribute to the ...