The above conclusions combined clarify the role of plk1 in mitotic entry. Plk1 inhibition slows the accumulation of active cdc25C that in turn slows the onset of the positive feedback responsible for ...
Aurora kinase A activity is inhibited by BRCA1. PLK1 induces CDC25C activation and WEE1 degradation as well as regulates NIMA-related-kinase 2 (NEK2) activity. NEK2 phosphorylates CEP250 and mediates ...
This study provides a convincing explanation for why HIV-1 Vif causes a qualitatively different cell cycle arrest to its accessory gene counterpart Vpr. The authors use elegant time-dependent ...
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