In other words, as plk1 inhibition impairs cdk1-cyclin B-independent cdc25 activation, it takes longer to reach a high level of cdc25 phosphorylation and active cdk1-cyclin B sufficient to sustain ...

CEP135 associates with SAS6 to link it to CPAP. Checkpoint kinase 1 (CHK1) phosphorylates and inhibits cell division cycle 25 (CDC25) A/C, which is responsible for dephosphorylating and activating ...

Jung J, Sung JS, Kwon S, Bae HE, Kang M-J, Jose J, Lee M, Pyun J-C (2025) Transmembrane protease serine 2 (TMPRSS2) inhibitors screened from an Fv-antibody library for preventing SARS-CoV-2 infection.

Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense (LMCBD), Military Institute of Engineering (IME), Praça General Tibúrcio 80, 22290-270 Rio de Janeiro, Brazil Center for ...

Acute myeloid leukemia (AML) is a heterogeneous malignant disorder of hematopoietic progenitor cells in which several genetic and epigenetic aberrations have been described. Despite progressive ...