The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

The canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell migration. While CXCR4 couples to G proteins and ...

The receptors and proteins were filtered from multiple datasets (Oncomine database) comparing prostate tumor tissue with normal tissue (based on Gene Ontology and statistical false-discovery rate ...

Calcific aortic valve disease (CAVD), and ensuing severe aortic stenosis (AS), is the foremost valvular disorder of aging, yet preventive therapies are lacking. A better understanding of the molecular ...

The focus of immunotherapy strategies targeting macrophage recruitment in CAC is primarily on the blocking of key chemokine and chemokine receptor pathways, such as CCL2/CCR2, CSF1/CSF1R, and ...

1 Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China 2 Key Laboratory of Birth Defects and Related Diseases of Women and Children ...