Frontiers22d
Cytokine concentration in peripheral blood of patients with colorectal cancer
IL-4), neutrophil chemotactic and N2 polarization-related cytokines (CXCL2, CXCL5, CXCL6, IL-8), dendritic cells (DCs) chemotactic-related proteins (CCL19, CCL20, and CCL21), Natural killer (NK) cell ...
gut.bmj17d
Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis
This compensatory increase in neutrophils was accompanied by increased levels of the chemokines CXCL1 and CXCL2, which attract neutrophils. Lipidomic analyses of colonic tissue from ...
Frontiers22d
Human Amnion Epithelial Cells and Their Derived Exosomes Alleviate Sepsis-Associated Acute Kidney Injury via Mitigating Endothelial Dysfunction
MIP-2/CXCL2, regulated upon activation normal T cell expressed and presumably secreted (RANTES)/CCL5, tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor A (VEGF-A). Measurements ...
ahajournals.org6d
Chemokine (C-C Motif) Ligand 2 Expressing Adventitial Fibroblast Expansion During Loeys-Dietz Syndrome Aortic Aneurysm Formation
Loeys-Dietz syndrome (LDS), caused by mutations in the TGF-β (transforming growth factor-β) signaling cascade, leads to aggressive thoracic aneurysms. While vascular smooth muscle cell (SMC) phenotype ...
eLife21d
Opposing Regulation of TNF Responses and IL-1β+ Macrophages by PGE2-cAMP and IFN-γ Signaling
The manuscript contains important findings regarding inflammatory macrophage subsets that have theoretical and/or practical applications beyond the field of rheumatology. The authors demonstrate with ...
BMJ20d
Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids
Objectives The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays a well-characterised role in the metabolism and activation of endogenous glucocorticoids (GCs). However, despite its ...