The blood-brain barrier border protects the brain by regulating the flow of molecules, peptides, and cells, but it also keeps out many therapeutics. Now, researchers have harnessed the power of a ...

More information: Jaroslaw Dulski et al, Global Presence and Penetrance of CSF1R -Related Disorder, Neurology Genetics (2024). DOI: 10.1212/NXG.0000000000200187 Provided by Mayo Clinic ...

Pexidartinib – which will be marketed under the Turalio trade name in the US - is an oral drug that inhibits CSF1R, KIT and FLT3, three molecular targets that can be used to unlock immune ...

It becomes the second FDA-approved drug for the disease after Daiichi Sankyo's Turalio (pexidartinib), a CSF1R, KIT, and FLT3 inhibitor that was cleared by the FDA in 2019 for TGCT associated with ...

These kinases, called colony-stimulating factor 1 receptors (CSF1R), release signals that bring other inflammation-causing cells to the tumor site. By blocking CSF1R, Romvimza stops the signal to ...

This valuable study reports the critical role of two cyclin-dependent kinases, CDK8 and CDK19, in spermatogenesis. The data presented are generally supportive of the main conclusion and are considered ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...

Department of Hygiene Toxicology, School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China Key Laboratory of Maternal and Child Health and Exposure Science, Guizhou Provincial ...

To further determine whether increased engraftment enhances efficacy, we utilized a CSF1R-inhibitor resistance approach. Interestingly, both localized and brain-wide engraftment in Alzheimer’s disease ...