Frontiers22d
Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene
Chimeric antigen receptor (CAR)-T cell immunotherapy is at the forefront of innovative cancer therapeutics. However, lack of standardization of cellular products within the same clinical trial and ...
eLife8d
Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice
This important study utilizes humanized mice, in which human immune cells are introduced into immune-deficient mice, to provide convincing evidence that two helper CD4 T-cell subsets, T-follicular ...
Physician's Weekly5d
Interleukin 15 A Potential Treatment Target for Severe Asthma
Interleukin 15 expression in asthmatic airways negatively correlated with lung function, a finding that improves ...
The Lancet27d
Clinical manifestations, disease penetrance, and treatment in individuals with SOCS1 insufficiency: a registry-based and population-based study
cInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany dInstitute of Genetic ...
eLife20d
The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes
Profiling T1D pancreata with CODEX high-parameter imaging reveals alterations in the cellular composition of islet and extra-islet compartments. Figure 1.A Left: Schematic of the workflow for ...
Cancer Research22d
Dynamics of Immune Reconstitution and Impact on Outcomes across CAR-T Cell Products in Large B-cell Lymphoma
1Department of Medicine, Weill Cornell Medicine, New York, New York. 2Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York.