Azer-cel is also rich in anti-apoptotic CCR7-positive cells, a feature that favours its survival. Hence, minimising the effects of host vs graft reaction, i.e. the rejection of the allogeneic cells.

Migration is primarily mediated by chemokine receptor CCR7, which is upregulated in response to homeostatic and inflammatory cues, guiding cDCs to dLNs. However, during type 2 immune responses, such ...

Using scRNA-seq, Jiang et al. observed that patients in the acute phase expressed high levels of DC_CCR7 in peripheral myeloid cells. DC_CCR7 is known to play crucial roles in T-cell activation, ...

USA), and phycoerythrin-Cy7-conjugated anti-human CCR7 (353227, BioLegend, USA) or intracellular staining for APC-conjugated anti-human IL-17A (17-7179-42, eBioscience, USA) and Foxp3 (320014, ...

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Objective To better understand the immune microenvironment of pancreatic ductal adenocarcinomas (PDACs), here we explored the relevance of T and B cell compartmentalisation into tertiary lymphoid ...